Drug Uses

Zoloft is a prescription medicine used to treat depression, panic disorder, obsessive-compulsive disorder (also called OCD) and posttraumatic stress disorder (also called PTSD) in adults. Zoloft is also used to treat OCD in children (ages 6-12) and adolescents (ages 12-17).

How Taken

Zoloft comes as a tablet to take it orally. It is usually taken once daily and may be taken with or without food. Take Zoloft exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Zoloft even if you feel well. Do not stop taking Zoloft without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Zoloft, tell your doctor if you have liver disease; kidney disease; suffer from seizures; or suffer from mania or have suicidal thoughts. You may not be able to take Zoloft, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Zoloft is in the FDA pregnancy category C. This means that it is unknown whether it will be harmful to an unborn baby. Do not take Zoloft without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zoloft passes into breast milk. Do not take Zoloft without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you take Zoloft once a day in the morning, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. If you take Zoloft once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not take a double dose to make up for a missed one.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Zoloft and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); an irregular heartbeat or pulse; low blood pressure (dizziness, weakness); high blood pressure (severe headache, blurred vision); or chills or fever. If you experience any of the following less serious side effects, continue taking Zoloft and talk to your doctor: headache; tremor, nervousness, or anxiety; nausea, diarrhea, dry mouth, or changes in appetite or weight; sleepiness or insomnia; or decreased sex drive, impotence, or difficulty having an orgasm. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at 25°C (77°F); excursions permitted to 15° - 30°C (59° - 86°F).

Overdose

Seek emergency medical attention. Symptoms of a Zoloft overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Zoloft may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness or dizziness while taking Zoloft.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Hundreds of thousands of people with moderate depression or anxiety have been put on powerful anti-depressants unnecessarily, the country's most senior medical experts will warn tomorrow.
Serious concerns about the overprescription of antidepressants such as Seroxat and Prozac will be spelled out by the two bodies regulating the safety and use of medicines in Britain.
They will advise that for people with mild to moderate depression, or with moderate anxiety, they may be better off seeking other treatment such as therapy or even daily exercise.
After months reviewing the international data on the drugs, known as SSRIs (selective serotonin reuptake inhibitors), the government's drugs regulator, the Medicines and Healthcare Products Regulatory Agency, has concluded that GPs are prescribing far too many pills for people who do not have a serious clinical condition.
They will warn doctors they need to think 'long and hard' before putting patients on the medication.
At a press conference tomorrow, Professor Kent Woods, mental health tsar Louis Appleby, and the chief executive of the National Institute for clinical Excellence (Nice), Andrew Dillon, will give their reasons for the warning.
It is expected thousands of people who are on the medication may want to come off it following tomorrow's announcement, but the experts will warn it is vital that they initially contact their doctor to talk about it. Anyone coming off SSRIs quickly can go through acute and dangerous withdrawal symptoms and become suicidal and paranoid.
Professor Woods will out line the findings of the review alongside the publication of new Nice guidelines to the NHS on the treatment of depression and anxiety.
Seroxat, the best-selling anti-depressant in the UK, will be described tomorrow as not suitable for every patient who is suffering from mild to moderate anxiety. The move comes after The Observer revealed last month that its manufacturer, GlaxoSmithKline, was marketing it to doctors specifically as a treatment for 'social anxiety disorders'.
Every year in Britain, some 13 million prescriptions are written out for SSRIs, such as Prozac. The drugs have enjoyed popularity over the past decade because they are much safer, with fewer side effects than the older tricyclic drugs which could easily kill patients who overdosed.
But concerns about SSRIs have emerged in recent years. Last year the government banned their prescription to people under 18s and they have been linked to a spate of suicides in young people in both the UK and the US.
European health authorities have also warned that extra care should be taken in prescribing SSRIs to people under 30.
The drugs, which were designed specifically to counter depression, have also been subjected to intensive scrutiny by the current health select committee investigation into the influence of the pharmaceutical industry.
MPs on the committee have heard concerns from campaigners that the anti-depressants were prescribed too liberally, with the result that millions of people are taking them with little benefit. Introduced to the UK 15 years ago, anti-depressants have been prescribed for a raft of lesser mental conditions such as anxiety disorders and phobias.
Concerns about the pills' addictive nature have led to fears that patients find it difficult to come off them.
Professor David Healy, a psychopharmacologist at Cardiff University, who has given evidence to the health select committee, called for the drug licensing authorities to go much further than merely trying to restrict the supply of anti-depressants.
'The MHRA should concentrate on telling people a little bit more about the risk of them getting hooked on anti-depressants, rather than simply warning the drugs should not be prescribed to those who are anxious,' Healy said.
An internal memo from Prozac's manufacturer, GlaxoSmithKline, written in 1998, revealed that trials of the drug in children were no better than a placebo when it came to relieving depression.
'It would be commercially unacceptable to include a statement that the efficacy had not been demonstrated, as this would undermine the profile [of the drug],' the memo stated.

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