Drug Uses

Transderm Scop is used to relieve nausea, vomiting, and dizziness associated with motion sickness. Transderm Scop is an anticholinergic medicine. Anticholinergics have many effects in the body. For example, they decrease the secretion of fluids, slow the stomach and intestine, and dilate the pupils.

How Taken

Transderm Scop comes as a patch to be placed on the skin behind your ear. Apply one patch to a clean, dry, hairless area behind the ear. The patch should be applied at least 4 hours before its effects will be needed. Each patch is good for 3 days. At the end of 3 days or when the Transderm Scop patch is no longer needed, remove the patch and throw it away. Wrap the patch in tissue or paper to avoid exposing anyone else to the remaining medication. Wash your hands and the area behind your ear thoroughly to remove any traces of Transderm Scop from the area. If a new patch needs to be applied, place a fresh patch on the hairless area behind your other ear.

Warnings/Precautions

Before using this medication, tell your doctor if you have kidney disease, liver disease, an enlarged prostate, difficulty urinating, bladder problems, or glaucoma. Transderm Scop is in the FDA pregnancy category C. This means that it is not known whether Transderm Scop will harm an unborn baby. Do not use Transderm Scop without first talking to your doctor if you are pregnant. It is not known whether Transderm Scop passes into breast milk. Do not use Transderm Scop without first talking to your doctor if you are breast-feeding a baby. Transderm Scop is not recommended for children use. Children are much more sensitive to the side effects of scopolamine.

Missed Dose

Remove the old patch as soon as you remember and apply a new patch to the same area behind the other ear. If it is almost time for the next dose, skip the missed dose altogether. Never take a double dose of Transderm Scop.

Possible Side Effects

Stop using Transderm Scop and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives). Other, less serious side effects may be more likely to occur. Continue to use Transderm Scop and talk to your doctor if you experience drowsiness; dry mouth, nose, or throat; restlessness, excitation, nervousness, or insomnia; blurred vision; dizziness; decreased appetite, nausea, or vomiting; difficulty urinating; or an irregular or fast heartbeat. Nausea, vomiting, dizziness, headache, and poor coordination have been reported when treatment lasting more than 3 days is discontinued. If you use Transderm Scop for more than 3 days, be aware that these side effects may occur when you stop. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Should be stored at controlled room temperature between 20°C - 25°C (68°F - 77°F).

Overdose

Seek emergency medical attention. Symptoms of a Transderm Scop overdose include drowsiness, dizziness, agitation, excitability, seizures or convulsions, hallucinations, and death.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Transderm Scop may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are using Transderm Scop.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Science Daily — When he began his research on motion sickness, Tom Stoffregen thought finding test subjects would be difficult. After all, it's called motion sickness because it results in headaches, dizziness, and, often, literally being sick. What kind of people would be eager to find out what it takes to make them throw up?
Tom Stoffregen monitors an experiment on his computer as the writer plays test subject. (Photo by Patrick O'Leary)
U students, it turns out. A lot of them.
"Undergraduate students, as a class, are suicidal," Stoffregen says bluntly. "I'm flooded with volunteers." He suspects the mass offering of students may have something to do with misplaced pride. "People think, 'You can't make me throw up,'" he says. Unfortunately for them, Stoffregen, a professor in the College of Education and Human Development's School of Kinesiology, has invested a lot of time and effort into finding out exactly what brings on motion sickness. And, like an academic 007, he's got a license to test.
Stoffregen's interest in motion sickness goes back to his childhood, when he was interested in space flight. He knew some astronauts suffered motion sickness, and after studying motion in graduate school and working for NASA, he wanted to find out why.
People have been motion sick for thousands of years, says Stoffregen, conjuring visions of dizzy Neanderthals and green-faced Vikings, but no one is sure why.
"There's an intuitive assumption that motion sickness is caused by the inner ear," he says. So far, the only approach to the problem has been studying how the sensations in the inner ear and eyes are different in situations when motion sickness results. For example, when a person is in a car and the eyes report movement but the body thinks it's stationary. Stoffregen thinks, however, that these perceptual differences are not what causes motion sickness. After all, nearly every person on this planet has experienced those perceptual differences at some point or another, and if we all reacted by being motion sick, well, let's just say the world would be a much different place. We'd have to take pilgrimages instead of planes, for one thing, and the rides at Disneyland would become the stuff of children's nightmares.
But if perceptual differences are not the cause of motion sickness, then what is? Movement, says Stoffregen. He measures the movement of people subjected to his sickness-inducing tests, and "the people who are going to get sick commence to move in really weird ways," he says, imitating the type of staggering walk typical after tequila night at the bar. Even when the subjects are strapped to an upright stretcher, the ones who feel sick still move a little. "They wriggle," says Stoffregen. Due to individual differences to sensitivity, only about half of Stoffregen's test subjects feel sick. Those who don't also don't wriggle, which makes Stoffregen think that movement is the key factor behind motion sickness.
Stoffregen has tested his theory extensively in the University's Human Factors Research Laboratory. His tests are all designed to make a person feel motion sick, but the test subjects remain stationary while the scenery around them shifts. In one test, a room-like structure is set on metal tracks. The subject stands on a platform as the "room," which has three walls and a ceiling, slides forward and backward on the tracks. The effect of the moving room has also been computerized, so a subject can stand in front of a huge screen and feel the same effects. Stoffregen also has an Xbox in his lab, which he asks test subjects to play. He doesn't even need special games. "The games are so realistic now, they can make people sick," he explains.
Being an undergraduate myself (though not suicidal) it only seemed right to undergo one test. Stoffregen directed me to the moving room, where he placed a two-by-four board on the platform before standing me on it. An inch of my flip-flops extended past each edge of the two-by-four, placing me just slightly off-balance. The décor was hurl-worthy on its own: The walls and ceiling were covered in white wallpaper veined with blue, giving the room the air of a huge marble crypt, and the focal piece was a bland map of the United States that only added to the atmosphere.
Stoffregen told me to focus on the map, then pulled the room backward a few feet. The map came zooming at my face, and it felt as if the floor had tilted backward 45 degrees. I took an involuntary step back (off the two-by-four), certain that I would fall over otherwise. Test subjects often endure 30 to 40 minutes of this, Stoffregen said, but 30 seconds was enough for me. No macho pride here; I fully believed he could make me toss my cookies.
Interestingly enough, Stoffregen says that no one knows why motion sickness often results in nausea and vomiting. As yet there is no scientific explanatinon for why seasickness makes you spew, carsickness makes you blow chunks, roller coasters make you ralph, or transoceanic flights to Osaka will make your stomach say sayonara to that sushi.
But despite undergoing tests designed to make people sick, no participants have ever actually done the technicolor yawn in the lab.
"We're interested in how [motion sickness] begins, not how it ends," Stoffregen says. "No on has ever thrown up in my lab. And that's a record I'm proud to keep."

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