Drug Uses

Nasacort is FDA approved for the treatment of the nasal symptoms of seasonal and year round allergies such as nasal congestion, itchy runny nose, and sneezing. Nasacort Nasal Spray is an unscented, thixotropic, water-based metered-dose pump spray formulation unit containing a microcrystalline suspension of triamcinolone acetonide in an aqueous medium.

How Taken

Nasacort Nasal Spray comes as a solution to inhale through the nose. It usually is inhaled one to four times a day at evenly spaced intervals. Before using triamcinolone, gently blow your nose to clear your nasal passages. Avoid blowing your nose for 15 minutes after inhaling the prescribed dose.

Warnings/Precautions

Before using this medication, tell your doctor if you have a viral, bacterial, or fungal infection of any kind. The absorption of this drug into the system can inhibit the body's ability to fight off infections. You may not be able to use Nasacort Nasal Spray if you have an infection. Nasacort Nasal Spray is in the FDA pregnancy C. This means that it is not known whether Nasacort Nasal Spray will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Nasacort Nasal Spray passes into breast milk. Do not use Nasacort Nasal Spray without first talking to your doctor if you are breast-feeding a baby. Nasacort Nasal Spray is not approved for children use younger than 12 years of age.

Missed Dose

If you miss a dose of Nasacort, use it as soon as remembered; do not use if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Possible Side Effects

Nasacort may cause irritation, stinging, burning, or dryness of the nasal passages. Sneezing, nosebleed, headache, lightheadedness, loss of taste, throat irritation or nausea may also occur. If these effects continue or become bothersome, inform your doctor. Unlikely but report promptly: persistent nose or throat irritation/soreness, white patchy areas. Very unlikely but report promptly: broken or damaged nasal membranes, unusual weakness, weight loss, nausea/vomiting, fainting, dizziness, vision changes. If you notice other effects not listed above, contact your doctor or pharmacist.

Storage

Store at Controlled Room Temperature, 20 to 25°C (68 to 77°F) away from sunlight and moisture. Avoid freezing. Keep out of reach of children.

Overdose

An overdose of this medication is not likely to occur. If you do think that an overdose has occurred, call an emergency room or poison control left for advice.

More Information

Avoid items or activities that are known allergens to you. Clean areas where dust or pet fur may aggravate your condition. Avoid exposing yourself to known sources of infection. Stay away from people with chicken pox, measles, or any other type of infection. Your immune system may not be strong enough to fight off an infection while using Nasacort.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Using Pitrakinra to inhibit interleukins-4 and -13 in the lungs may significantly reduce asthma symptoms, according to an article in the medical journal The Lancet, this week's issue.
The authors explain that doctors and scientists have believed for over twenty years that cytokines, such as interleukin-4 or interleukin-13 play a vital role in the onset and development of clinical asthma. However, there has been no scientific evidence that this might be so.
Dr Malinda Longphre, Aerovance Inc, Berkeley, California, USA and team carried out two separate Phase II clinical trials, where patients received Pitrakinra. In the first study 12 volunteers received 25mg of Pitrakinra by subcutaneous injection once per day. The patients in the second study were given either 60mg of Pitrakinra twice a day by nebulization, and another 16 received a placebo. In both trials the volunteers inhaled allergens before and four weeks after treatment - the allergens are designed to induce an asthma attack, the patient during an asthma attack of this type finds it harder to expel air.
The primary endpoint for the first trial was a maximum percentage drop in forced expiratory volume (FEV1)** in one second over 4-10 hours after receiving the allergen. In the second study the primary endpoint was average percentage fall in FEV1 over 4-10 hours after being given the allergen. If smaller falls in FEV1 during the asthma attack for the Pitrakinra group compared to the placebo group were detected, this would indicate that the allergic response had been reduced by Pitrakinra.
In the first study, say the researchers, the maximum percentage fall in FEV1 was 17.1% in the Pitrakinra and 23.1% in the placebo groups - a comparable difference of 26%. In the second study the average percentage drop in FEV1 was 4.4% in the Pitrakinra versus 15.9% in the placebo group - in other words, it was over three and a half times less in the Pitrakinra group.
"The effects of pitrakinra on late phase asthmatic response are promising when compared with similar studies with other successful anti-inflammatory asthma therapies...whether the effect is due to inhibition of interleukin-13 alone, or both interleukin-13 an interleukin-4, is not yet known. Future studies of this drug, as well as molecules that specifically inhibit interleukin-13, in asthmatic individuals of all levels of severity over longer periods of time are clearly warranted," the writers conclude.

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