Drug Uses

The antidepressant Lexapro is a member of the family of medications known as selective serotonin reuptake inhibitors (SSRIs). Lexapro offer advantages in the treatment of depression and generalized anxiety disorder.

How Taken

Lexapro comes as a tablet and a liquid taken it orally. It is usually taken once daily and may be taken with or without food. Take Lexapro exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Lexapro even if you feel well. Do not stop taking Lexapro without talking to your doctor. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Lexapro, tell your doctor if you have liver disease, have kidney disease, suffer from seizures, or suffer from mania or have suicidal thoughts. You may not be able to take Lexapro, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Lexapro should not be taken during treatment with citalopram (Celexa). Also, if you have had an allergic reaction to citalopram (Celexa), you may also have an allergic reaction to Lexapro. Do not take Lexapro without first talking to your doctor if you have had an allergic reaction to either medication in the past. Lexapro is in the FDA pregnancy category C. This means that it is not known whether Lexapro it will be harmful to an unborn baby. Do not take Lexapro without first talking to your doctor if you are pregnant or could become pregnant during treatment. Lexapro passes into breast milk and may affect a nursing infant. Do not take Lexapro without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Lexapro and call your doctor immediately or seek emergency medical treatment:
-an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
-an irregular heartbeat or pulse;
-low blood pressure (dizziness, weakness);
-high blood pressure (severe headache, blurred vision); or
-chills or fever. If you experience any of the following less serious side effects, continue taking Lexapro and talk to your doctor:
-headache, tremor, nervousness, or anxiety;
-nausea, diarrhea, dry mouth, or changes in appetite or weight;
-sleepiness or insomnia; or
-decreased sex drive, impotence, or difficulty having an orgasm.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store Lexapro at room temperature away from moisture and heat.

Overdose

Seek emergency medical attention. Symptoms of a Lexapro overdose include nausea, vomiting, tremor, drowsiness, dizziness, sweating, and a fast heartbeat.

More Information

Do not take Lexapro if you: You have a known sensitivity or allergy to any component of Lexapro.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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A new neurobiological study has found that a synthetic form of THC, the active ingredient in cannabis, is an effective anti-depressant at low doses. However, at higher doses, the effect reverses itself and can actually worsen depression and other psychiatric conditions like psychosis.
It has been known for many years that depletion of the neurotransmitter serotonin in the brain leads to depression, so SSRI-class anti-depressants like Prozac and Celexa work by enhancing the available concentration of serotonin in the brain. However, this study offers the first evidence that cannabis can also increase serotonin, at least at lower doses.
Laboratory animals were injected with the synthetic cannabinoid WIN55,212-2 and then tested with the Forced Swim test -- a test to measure "depression" in animals; the researchers observed an antidepressant effect of cannabinoids paralleled by an increased activity in the neurons that produce serotonin. However, increasing the cannabinoid dose beyond a set point completely undid the benefits, said Dr. Gabriella Gobbi of McGill University.
"Low doses had a potent anti-depressant effect, but when we increased the dose, the serotonin in the rats' brains actually dropped below the level of those in the control group. So we actually demonstrated a double effect: At low doses it increases serotonin, but at higher doses the effect is devastating, completely reversed."
The anti-depressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids," which are released under conditions of high stress or pain, explained Dr. Gobbi. They interact with the brain through structures called cannabinoid CB1 receptors. This study demonstrates for the first time that these receptors have a direct effect on the cells producing serotonin, which is a neurotransmitter that regulates the mood.
Dr. Gobbi and her colleagues were prompted to explore cannabis' potential as an anti-depressant through anecdotal clinical evidence, she said. "As a psychiatrist, I noticed that several of my patients suffering from depression used to smoke cannabis. And in the scientific literature, we had some evidence that people treated with cannabis for multiple sclerosis or AIDS showed a big improvement in mood disorders. But there were no laboratory studies demonstrating the anti-depressant mechanism of action of cannabis."
Because controlling the dosage of natural cannabis is difficult -- particularly when it is smoked in the form of marijuana joints -- there are perils associated with using it directly as an anti-depressant.
"Excessive cannabis use in people with depression poses high risk of psychosis," said Dr. Gobbi. Instead, she and her colleagues are focusing their research on a new class of drugs which enhance the effects of the brain's natural endo-cannabinoids.
"We know that it's entirely possible to produce drugs which will enhance endo-cannabinoids for the treatment of pain, depression and anxiety," she said.
The study, published in the October 24 issue of The Journal of Neuroscience, was led by Dr. Gabriella Gobbi of McGill University and Le Centre de Recherche Fernand Seguin of Hôpital Louis-H. Lafontaine, affiliated with l'Université de Montréal. First author is Dr. Gobbi's McGill PhD student Francis Bambico, along with Noam Katz and the late Dr. Guy Debonnel* of McGill's Department of Psychiatry.

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