Drug Uses

Use Eurax to treat scabies or to reduce itching associated with certain conditions.

How Taken

Shake the lotion well before use. Apply a thin layer of the cream or lotion to all body parts from the neck down to the soles of your feet (scabies does not usually infect the head). Apply the medication to dry skin and rub it in well. Leave the medication on for 24 hours, then, without washing, apply a second dose. Thoroughly wash off the medication 48 hours after the last application.

Warnings/Precautions

Do not use more of this medication than is recommended. Do not take this medication by mouth. Avoid application to the mouth, nose, or eyes. Treat sexual and other close contacts who are also infected. To prevent reinfection, wash all clothing, hats, bed clothes, bed linens, hair brushes, and combs with a strong cleanser in hot water to remove any mites or eggs.

Missed Dose

Two doses of Eurax, 24 hours apart, are recommended. If the second dose is missed, retreatment may be necessary. Contact your doctor or pharmacist if you miss a dose.

Possible Side Effects

You are not likely to experience serious side effects. Stop using Eurax and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Storage

Store Eurax at room temperature away from moisture and heat.

Overdose

Seek emergency medical attention. Symptoms of an overdose (after ingestion) include a burning feeling in the mouth; irritation or inflammation of the mouth, throat, and stomach lining; nausea; vomiting; and abdominal pain.

More Information

Do not apply this medication to the eyes, nose, or mouth. Flush with water if you get medication in any of these areas.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Jan. 14, 2004 — Antiparasitic therapy is appropriate and reduces the number of seizures associated with neurocysticercosis, according to the results of a double-blind, randomized trial published in the Jan. 15 issue of the New England Journal of Medicine. The editorialist agrees.
"Neurocysticercosis is the main cause of adult-onset seizures in the developing world," write Héctor H. Garcia, MD, and colleagues from the Cysticercosis Working Group in Lima, Peru. "Whether therapy with antiparasitic agents results in improved seizure control has been questioned because of the lack of adequate, controlled studies."
In this study, 120 patients with living cysticerci in the brain and seizures treated with antiepileptic drugs received either 800 mg of albendazole and 6 mg of dexamethasone daily or two placebos for 10 days. Follow-up continued for 30 months or until patients were seizure-free for six months after tapering doses of their antiepileptic drugs.
In the albendazole group, the number of seizures decreased by 46% (95% confidence interval [CI], –74% to 83%) during months 2 to 30 after treatment. Although the decrease in total number of seizures and in number of partial seizures was not statistically significant, the number of seizures with generalization decreased significantly by 67% (95% CI, 20% to 86%).
Most of the difference in the number of partial seizures resulted from a few patients with many seizures during follow-up. The proportions of patients with partial seizures during follow-up were similar in both groups (19 of 57 in the albendazole group and 16 of 59 in the placebo group), but more patients in the placebo group had seizures with generalization (22 of 59 vs. 13 of 57; risk ratio, 1.63; 95% CI, 0.91 to 2.92).
More intracranial cystic lesions resolved in the albendazole group than in the placebo group. Except for abdominal pain, adverse effects were similar in both groups.
"In patients with seizures due to viable parenchymal cysts, antiparasitic therapy decreases the burden of parasites and is safe and effective, at least in reducing the number of seizures with generalization," the authors write, noting that enlarging cysts may cause intracranial hypertension. "Not to undertake antiparasitic therapy in such cases could allow disease progression and even risk the patient's life. An additional, and commonly neglected, point of discussion is that most patients feel highly uncomfortable leaving a parasite living in their brain."
The Food and Drug Administration, the National Institute of Allergy and Infectious Diseases, and SmithKline Beecham supported this study.
In an accompanying editorial, Julio Sotelo, MD, from the National Institute of Neurology and Neurosurgery in Mexico City, Mexico, notes that praziquantel and albendazole are effective for destroying brain cysticerci, have minimal toxicity, and are inexpensive and therefore practical because most infected patients are in lower economic strata.
Dr. Sotelo recommends studies with longer follow-up periods but concludes that "the expeditious elimination of parasites is beneficial, and cysticidal treatment should be administered to all patients with active parenchymal neurocysticercosis."
In an accompanying perspective, James H. Maguire, MD, points out that the treatment was not completely effective and suggests additional research to determine whether longer or repeated therapy will further reduce seizures and cysticerci.
"Although the study by Garcia et al. represents an important advance in the management of neurocysticercosis, it will benefit only patients who have access to sophisticated medical care," Dr. Maguire writes. "Most affected people live in poor countries and do not have access to computed tomography [CT], magnetic resonance imaging [MRI], or reliable serologic tests, which are necessary for the detection of cysticerci in the brain or for confirmation of the diagnosis. For this reason, prevention is a priority, and there are measures that effectively interrupt transmission at every stage of the cycle."

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