Drug Uses

Use Estrandiol to reduce moderate to severe menopausal symptoms, to treat vulval and vaginal atrophy, treat certain cancers in special situations and prevent the thinning of bones.

How Taken

Talk to your local physician or pharmacist. You and your doctor should reevaluate whether or not you still need estrogens at least every six months.

Warnings/Precautions

If you think you may be pregnant, do not use any form of estrogen-containing drug. Using Estrandiol while you are pregnant may cause your unborn child to have birth defects. Estrandiol does not prevent miscarriage.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Possible Side Effects

The following side effects have been reported with use of this medicine: nausea and vomiting; breast tenderness or enlargement; enlargement of benign tumors; retention of excess fluid (this may make some conditions worsen, such as asthma, epilepsy, migraine, heart disease, or kidney disease); a spotty darken of the skin, particularly on the face.

Storage

Store at controlled room temperature 15°C to 30°C (59°F to 86°F). Keep this and all drugs out of the reach of children.

Overdose

In case of overdose, call your doctor, hospital or poison control center immediately.

More Information

You are cautioned to discuss very carefully with your doctor or health care provider all the possible risks and benefits of long-term estrogen and progestin treatment as they affect you personally.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Uterine Cancer Also called: Endometrial cancer The uterus, or womb, is an important female reproductive organ. It is the place where a baby grows when a women is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of uterine cancer include * Unusual vaginal bleeding or discharge * Trouble urinating * Pelvic pain * Pain during intercourse Uterine cancer usually occurs after menopause. Being obese and taking estrogen-alone hormone replacement therapy also increase your risk. Treatment varies depending on your overall health, how advanced the cancer is and whether hormones affect its growth. Treatment is usually a hysterectomy, which is surgery to remove the uterus. Other options include hormone therapy and radiation. About the Uterus and Endometrium The uterus is a hollow organ, about the size and shape of a medium-sized pear. The uterus has two main parts. The lower end of the uterus, which extends into the vagina, is called the cervix. The upper part is the body of the uterus, also known as the corpus. (Corpus is the Latin word for body.) The body of the uterus has two layers. The inner layer is called the endometrium. (endo is Greek for inside and metrium is Greek for uterus.) The outer is called the myometrium. (myo is Greek for muscle.) The myometrium is the thick layer of muscle that pushes the baby out during birth. Hormone changes during a woman?s menstrual cycle cause the endometrium to change. During the early part of the cycle, the ovaries (glands on either side of the uterus that produce eggs) produce estrogens. This causes the endometrium to thicken in order to nourish an embryo in case the woman becomes pregnant. After an ovary releases an egg (called ovulation), if pregnancy does not occur, estrogen is produced in lower amounts and more progesterone is made. This causes the innermost layer of the lining to prepare to shed. By the end of the cycle, the lining is shed from the uterus and becomes the menstrual flow. This cycle repeats throughout a woman?s life until menopause (change of life). Cancers of the Uterus and Endometrium Adenocarcinomas: Nearly all endometrial cancers (about 95%) are cancers of glandular cells, called adenocarcinomas. Most of these are described as typical adenocarcinomas. Most experts divide endometrial adenocarcinomas into two types. In type 1, the cancer looks most like normal endometrium and may not be a very dangerous, life-threatening cancer. It only occasionally spreads to other tissues. This type is often called endometrioid, meaning it looks like normal endometrial lining tissue. There are three grades of tumor, with grade three being more aggressive with a greater risk of invasion to the uterine wall (myometrium), local and distant metastases. Sometimes, in addition to glandular cells, endometrial cancers also contain squamous cells (the type of cells found on the surface of the cervix and the skin). If the squamous cells look benign (non-cancerous) under a microscope and the glandular cells look cancerous, these tumors are called adenocarcinomas with squamous differentiation (they used to be called adenoacanthomas, although this term is now used much less often). If the squamous areas and glandular areas both look malignant (cancerous), these tumors are called adenosquamous carcinomas. Although these look different under the microscope, they are treated the same as typical endometrial adenocarcinomas. However, adenosquamous carcinomas tend to be more aggressive. Type 2 endometrial cancer doesn?t look at all like normal endometrium. It is much more likely to spread and is, therefore, more dangerous, These types are called either papillary serous adenocarcinomas or clear cell adenocarcinomas. About 10% of endometrial cancers are these types. Because they are different from the usual kind and tend to grow and spread they are treated more aggressively than the endometrioid cancers. Women with this type of cancer tend to be older by five to ten years on average, than women with type 1. Uterine sarcomas: Uterine cancers that do not come from glandular tissue of the endometrium are called uterine sarcomas. They are less common, but can still involve other parts of the endometrium. These include: * stromal sarcomas, which start in the stroma (supporting connective tissue) of the endometrium * malignant mixed mesodermal tumors (MMMTs or carcinosarcomas), which may combine features of endometrial carcinoma and those of sarcomas * leiomyosarcomas, which start in the myometrium or muscular wall of the uterus These three types of cancer are not discussed in this document because their treatment and prognosis (the outlook for survival) are different from the most common cancers of the endometrium. These cancers are discussed in the document ?Uterine Sarcomas,? which is available from the American Cancer Society upon request or online. Cervical cancers: Cancers of the cervix are different from cancers of the body of the uterus and are described in another American Cancer Society document.

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