Drug Uses

Effexor XR is a potent inhibitor of the reuptake of serotonin and norepinephrine-two neurotransmitters thought to play important roles in the pathophysiology of depression. Correcting the imbalance of these two chemicals may help relieve symptoms of depression.

How Taken

Effexor XR comes as a capsule to take by mouth. It is usually taken once a day and should be taken with food. Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water, or it may be administered by carefully opening the capsule and sprinkling the entire contents on a spoonful of applesauce. This drug/food mixture should be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the pellets.

Warnings/Precautions

Before starting Effexor XR, tell your doctor about any medicines you're taking, including over-the-counter drugs and herbal supplements. If you take MAOIs you should not take Effexor XR. If you are taking antidepressants you should be watched closely for signs that your condition is getting worse or that you are becoming suicidal, especially when you first start therapy, or when your dose is increased or decreased. You should also be watched for becoming agitated, irritable, hostile, impulsive, or restless. Such symptoms should be reported to your doctor right away. Effexor XR may raise blood pressure in some patients, so blood pressure should be monitored regularly. When you suddenly stop using or quickly lower your daily dose of Effexor XR, discontinuation symptoms may occur. Talk to your doctor before discontinuing or reducing your dose of Effexor XR. Pregnant or nursing women shouldn't take any antidepressant without consulting their doctor. Until you see how Effexor XR affects you, be careful doing such activities as driving a car or operating machinery. Avoid drinking alcohol while taking Effexor XR.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Effexor XR and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); seizures; or an irregular heartbeat or severely high blood pressure (blurred vision, headache). Other, less serious side effects may be more likely to occur. Continue to take Effexor XR and talk to your doctor if you experience nausea, vomiting, upset stomach, abdominal pain, or loss of appetite or weight; dry mouth; drowsiness or dizziness; mild tremor, anxiety, or agitation; insomnia; abnormal dreams; sexual problems such as impotence, abnormal ejaculation, difficulty reaching orgasm, or decreased libido; sweating; yawning; or increase in blood cholesterol levels (detected by blood tests); Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store Effexor XR at room temperature (68F to 77F or 20C to 25C). Keep Effexor XR away from children.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of an Effexor XR overdose may include dizziness, drowsiness, numbness, nausea, irregular heartbeats, seizures, and unconsciousness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Effexor XR may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness, dizziness, and confusion Do not stop taking Effexor XR without first talking to your doctor. Your doctor may need to gradually reduce the dose before stopping the medication completely. Stopping the medication suddenly may cause unpleasant side effects to occur.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Thousands of people in the UK could be hooked on the anti-depressant drug Seroxat, without knowing it.
Dr David Healy, a UK expert in antidepressants, has said he has seen records of trials carried out by the manufacturers which showed healthy volunteers were suffering withdrawal symptoms after taking the drug for just a couple of weeks.
He said more than half of people on Seroxat may have "significant" withdrawal problems.
He said: "For most people who take the drug, one of the key points that will concern people is that Seroxat (paroxetine) could make you physically dependent."
Dr Healy, director of the North Wales department of psychological medicine was given access to the results of early trials of the drugs while a witness in a US case.
The case dealt with a seperate concern about the drug, which is that some people who take it could become violent towards themselves or others.
The family of David Snell won a $6.4m payout from manufacturers GlaxoSmithKline (GSK) after Mr Snell was found to have murdered three members of his family, and himself, after taking the drug for just two days.
The company denies the link and is appealing against the decision.
Two weeks earlier, in Australia, a judge ruled Sertraline, a drug in the same family, had caused David Hawkins to murder his wife and attempt to kill himself.
Dr Healy told BBC News Online, of the 100m people world-wide who were on Seroxat, one in 1,000 could have a suicidal reaction.
There have been concerns expressed in the past about antidepressants such as Prozac making healthy people with no history of mental illness feel violent.
New generation
Seroxat is part of a family of antidepressants called SSRIs (selective serotonin re-uptake inhibitor) which were introduced to the market in the early 1990s.
They were a replacement for benzodiazepines such as Valium and Librium - and their selling point was that people would not become physically dependent on them, unlike the older drugs.
Dr Healy was given access to GSK's archives because he was an expert witness in the Snell case.
And he said a trial a study of 34 healthy company workers by GSK, carried out before Seroxat was licensed, showed 25% became agitated.
Dr Healy believes a small number could be so disturbed by the effects of SSRIs that they could kill.
He said some of those involved in the pre-licensing trial had gone on to "suicidal acts".
He wrote to the Medicines Control Agency, which grants drug licenses in the UK, and said: "The relationship between their intake of paroxetine (Paxil/Seroxat) and later suicidal acts is a matter about which neither you, nor SmithKline Beecham should be sanguine."
Dr Healy said the company has failed to pass on information to patients or doctors.
He says a study which looked at the effect of stopping the drug for people who had successfully been treated for the depression showed many got worse.
The company argued this meant the drug should be licensed for long term treatment of depression.
Dr Healy says this is potentially more evidence that the participants in the trial were suffering withdrawal symptoms
He said the drug should carry warnings that some people who take it may experience violent or unusual thoughts, which were linked to the drug and not their condition.
And he said doctors who were treating people who suffered symptoms after coming off the drug "should be aware that maybe the underlying problem has cleared up and maybe the symptoms are due to withdrawal."
A World Health Organization report which ranked antidepressants in order of withdrawal problems found Seroxat was the hardest to come off.
Prozac (fluoxetine) was seventh.
Alan Chandler, a spokesman for GSK denied Seroxat was causing dependency, withdrawal symptoms or violent tendencies.
He said independent analysis last year by the MCA and others had concluded SSRIs did not cause dependency.
He said: "Withdrawal symptoms may occur with all SSRIs if treatment is abruptly stopped. This is not a sign of addiction or depression."

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