Drug Uses

Allegra-D is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 12 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, itchy nose/palate/ and/or throat, itchy/watery/red eyes, and nasal congestion.

How Taken

The recommended dose of Allegra-D is one tablet twice daily for adults and children 12 years of age and older. It is recommended that the administration of Allegra-D with food should be avoided. A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.

Warnings/Precautions

Do not take Allegra-D if you have taken a monoamine oxidase inhibitor (MAOI) in the last 14 days; asthma or another lung disease; diabetes; thyroid problems; glaucoma or increased pressure in the eye; urinary retention or an enlarged prostate; kidney or liver disease; or heart disease, high blood pressure, or an irregular heartbeat. You may not be able to take Allegra-D, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Allegra-D is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take Allegra-D without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known if Allegra-D passes into breast milk. Do not take Allegra-D without first talking to your doctor if you are breast-feeding a baby. Allegra-D is not approved for use by children younger than 12 years of age.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Possible Side Effects

Nausea, stomach upset, trouble sleeping, headache, or cold symptoms may occur. If these persist or worsen, notify your doctor promptly. Unlikely but report promptly: dizziness, mental/mood changes, fast heartbeat, fever. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular heartbeat. Although drowsiness is very uncommon at usual doses under normal circumstances, be aware that drowsiness may occur and may affect the ability to perform tasks requiring alertness (e.g., driving). If you notice other effects not listed above, contact your doctor or pharmacist.

Storage

Store at room temperature between 68 and 77 degrees F (20-25 degrees C) away from sunlight and moisture.

Overdose

In large doses, Allegra-D may give rise to giddiness, headache, nausea, vomiting, sweating, thirst, tachycardia, precordial pain, palpitations, difficulty in micturition, muscular weakness and tenseness, anxiety, restlessness, and insomnia. You can present a toxic psychosis with delusions and hallucinations or you may develop cardiac arrhythmias, circulatory collapse, convulsions, coma, and respiratory failure.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Allegra-D may cause dizziness. If you experience dizziness, avoid these activities. Do not take Allegra-D close to a dose of an antacid that contains aluminum or magnesium. These antacids may decrease the effects of Allegra-D.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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"It has long been debated whether people who develop asthma have a genetic propensity to develop allergies, or atopy," said Darryl C. Zeldin, M.D., a senior investigator at the National Institute of Environmental Health Sciences (NIEHS). "This new research shows that 56.3 percent of asthma cases are attributed to atopy." Atopy is a condition that results from gene-environment interactions and can be measured by a positive skin test to allergens (or allergy causing substances in the environment).
The study, in the Journal of Allergy and Clinical Immunology, was conducted by researchers at the National Institute of Environmental Health Sciences (NIEHS) and the National Institute of Allergy and Infectious Diseases, both parts of the NIH. The data come from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the population of the United States.
"Sensitization to cat appears to be a strong risk factor for asthma in this study," said Zeldin. Zeldin and his co-authors, however, point out that some research shows that exposure to cats, particularly early in life, may be a protective factor. "We are not advocating parents get rid of pets, but if you suspect that you or your child might have cat allergies or get asthmatic-like symptoms, you should consult with a physician about the best course of action for your family," added Zeldin.
The NIH researchers looked at skin test data for ten allergens. A positive skin test reaction to cat allergens accounted for 29.3 percent of the asthma cases, followed by the fungus Alternaria at 21.1 percent and white oak at 20.9 percent. "Each of 10 allergen-specific skin tests was strongly associated with asthma; however, after adjustment by a variety of subject characteristics and all the allergens, only skin tests to cat, Alternaria and white oak were independently and positively associated with asthma," said Peter Gergen, M.D., M.P.H, of NIAID's Division of Allergy, Immunology and Transplantation, a co-author on the paper.
Other allergens tested include: Ragweed, dustmites, Russian thistle, Bermuda grass, peanuts, perennial rye and german cockroach. Approximately 10,500 individuals participated in the skin testing. During these tests, skin was exposed to allergy-causing substances (allergens) and a positive test was determined by the size of the reaction on the skin.
"This study tells us that allergy is a major factor in asthma," Gergen said. "But this study also tells us is that there are many people who get asthma who don't have allergies. We need to do more research to understand what is causing the asthma that is not related to allergies."
"This study confirms that the environment plays a major role in the development of asthma," said Zeldin. "Given the complexity of this disease it won't be easy, but if we can prevent, block or reverse atopy, we could reduce a large proportion of asthma cases."
Reference: Arbes SJ, Gergen,PJ Vaughn B, Zeldin DC. Asthma cases attributable to atopy: Results from the Third National Health and Nutrition Examination Survey. Journal of Allergy and Clinical Immunology. September, 2007.

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